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Acta Diabetol. 2019 Jul;56(7):755-765. doi: 10.1007/s00592-019-01358-x. Epub 2019 May 15.

Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study.

Author information

1
Faculty of Kinesiology, Sport, and Recreation, and Alberta Diabetes Institute, University of Alberta, Edmonton, AB, T6G 2H9, Canada.
2
School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia - Okanagan, Kelowna, BC, V1V 1V7, Canada.
3
Faculty of Physical Activity Sciences, Université de Sherbrooke, Sherbrooke, QC, J1K 2R1, Canada.
4
Research Center on Aging, CIUSSSE - CHUS, Sherbrooke, QC, J1H 4C4, Canada.
5
Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.
6
Augustana Faculty, University of Alberta, Camrose, AB, T4V 2R3, Canada.
7
Faculty of Kinesiology, University of Calgary, Calgary, AB, T2N 1N4, Canada.
8
Department of Kinesiology, McMaster University, Hamilton, ON, L8S 4K1, Canada.
9
Department of Medicine, Université Laval, Quebec City, QC, G1V 0A6, Canada.
10
Department of Agriculture and Food Science, Université Laval, Quebec City, QC, G1V 0A6, Canada.
11
DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, MB, R3E 3P4, Canada.
12
Departments of Medicine, Cardiac Sciences and Community Health Sciences, Faculties of Medicine and Kinesiology, University of Calgary, Calgary, AB, T2N 1N4, Canada.
13
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2E1, Canada.
14
Faculty of Health and Medical Sciences, University of Surrey, Guilford, GU2 7WG, UK.
15
Centre for Health Evaluation and Outcome Sciences, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada.
16
Faculty of Kinesiology, Sport, and Recreation, and Alberta Diabetes Institute, University of Alberta, Edmonton, AB, T6G 2H9, Canada. nboule@ualberta.ca.
17
School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia - Okanagan, Kelowna, BC, V1V 1V7, Canada. jonathan.little@ubc.ca.

Abstract

AIM:

To examine the effect of walking before dinner on 24-h glycemic control in individuals with type 2 diabetes using the standardized multi-site Exercise-Physical Activity and Diabetes Glucose Monitoring (E-PAraDiGM) Protocol.

METHODS:

Eighty participants were studied under two conditions (exercise vs. non-exercise control) separated by 72 h in a randomized crossover design. Each condition lasted 2 days during which standardized meals were provided. Exercise consisted of 50 min of treadmill walking at 5.0 km/h before the evening meal, while control involved 50 min of sitting. The primary outcome measure was mean glucose during the 24-h period following exercise (or sitting) measured by continuous glucose monitoring.

RESULTS:

Of the 80 participants who were initially randomized, 73 completed both exercise and control. Sixty-three participants [29 males, 34 females; age = 64 ± 8 years, body mass index = 30.5 ± 6.5 kg/m2 and HbA1c = 51 ± 8 mmol/mol (6.8 ± 0.7%), mean ± SD] complied with the standardized diets and had complete continuous glucose monitoring data. Exercise did not affect mean 24-h glucose compared to control (0.03 mmol/L; 95% CI - 0.17, 0.22, P = 0.778) but individual differences between conditions ranged from - 2.8 to +1.8 mmol/L. Exercise did not affect fasting glucose, postprandial glucose or glucose variability. Glucose concentrations measured by continuous glucose monitoring were reduced during the 50 min of walking in exercise compared to sitting in control (- 1.56 mmol/L; 95% CI - 2.18, - 0.95, p < 0.001).

CONCLUSION:

Contrary to previous acute exercise studies, 50 min of walking before dinner in the E-PAraDiGM protocol did not affect 24-h glucose profiles. However, highly heterogeneous responses to exercise were observed.

TRIAL REGISTRATION:

NCT02834689.

KEYWORDS:

Continuous glucose monitoring; Glycemic control; Physical activity; Type 2 diabetes; Walking

PMID:
31093764
DOI:
10.1007/s00592-019-01358-x
[Indexed for MEDLINE]

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