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Food Sci Biotechnol. 2018 Nov 19;28(3):857-864. doi: 10.1007/s10068-018-0516-9. eCollection 2019 Jun.

The protective effects of Gastrodia elata Blume extracts on middle cerebral artery occlusion in rats.

Author information

1
1Department of Senior Healthcare, BK21 Plus Program, Graduate School, Eulji University, Seongnam-si, Gyunggi-do 13135 Republic of Korea.
2
2Muju Wellness Food Project Team, Jeonju University, Jeonju-si, Jeonrabuk-do 55069 Republic of Korea.
3
3Department of Food Technology and Service, Eulji University, Seongnam-si, Gyunggi-do 13135 Republic of Korea.

Abstract

To investigate the effects of Gastrodia elata Blume (GEB) and 4-hydroxybenzyl alcohol (HBA) on brain damage, GEB or HBA was administered orally for 14 days before middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the proportion of circling was significantly reduced in the GEB (79%) or HBA (69%) group compared to the MCAO group (100%) in the corner test, and the removal time in the adhesive removal test was significantly decreased in the GEB (117 ± 21.0 s) and HBA (101 ± 20.9 s) groups compared to the MCAO group (161 ± 12.6 s). GEB treatment significantly reduced infarct volume compared to the MCAO group. In the GEB and HBA group, necrosis of nerve cells in hippocampus and cortex, expressions of TNF-α and TUNEL positive cells were significantly reduced compared to the MCAO group. These results suggest that GEB and HBA prevents brain damage by anti-inflammatory and anti-apoptotic effects.

KEYWORDS:

4-Hydroxybenzyl alcohol; Brain ischemia; Gastrodia elata Blume; Middle cerebral artery occlusion; Rat

PMID:
31093444
PMCID:
PMC6484056
[Available on 2019-11-19]
DOI:
10.1007/s10068-018-0516-9

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