Format

Send to

Choose Destination
Hemoglobin. 2019 Jan;43(1):60-62. doi: 10.1080/03630269.2019.1582429. Epub 2019 May 15.

Unstable Hemoglobin Variants: The Need for Clinical Vigilance in Infants with Congenital Jaundice.

Author information

1
a Department of Hematology/Oncology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , Guangdong Province , People's Republic of China.
2
b Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , Guangdong Province , People's Republic of China.

Abstract

Unstable hemoglobin (Hb) variants are a rare etiology of congenital jaundice caused by hemolytic anemia. For infant patients with jaundice this disorder is often under diagnosed or the last consideration. We report a 14-month-old boy, who presented with a long-standing jaundice. His diagnosis of Hb Sabine [β91(F7)Leu→Pro; HBB: c.275T > C] was not revealed until gene sequencing of the β-globin gene was performed.

KEYWORDS:

Hb Sabine; Hemoglobinopathies; hemolytic anemia; neonatal jaundice; unstable hemoglobin (Hb)

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center