Format

Send to

Choose Destination
Childs Nerv Syst. 2019 May 14. doi: 10.1007/s00381-019-04159-3. [Epub ahead of print]

Paediatric intracranial aneurysms: a British institutional review.

Author information

1
Department of Paediatric Neurosurgery, Birmingham Children's Hospital, Birmingham, UK.
2
Department of Neurosurgery, Queen Elizabeth Hospital, Birmingham, UK. samedtalibi@nhs.net.
3
Department of Neuroradiology, Queen Elizabeth Hospital, Birmingham, UK.

Abstract

INTRODUCTION:

Paediatric intracranial aneurysms are rare, with a differing natural history and thought to account for only up to 7% of all intracranial aneurysms. There is much uncertainty that surrounds the prevalence of unruptured intracranial aneurysms and it is estimated to be anywhere between 2 and 90 per 1000. This is the largest British single-centre analysis of paediatric intracranial aneurysms. We present the patient course from their initial presentations to the outcome of treatment and evaluate a serial assessment of adequacy of aneurysmal obliteration radiologically.

RESULTS:

Twenty-two paediatric cases were identified that required treatment. The median age of presentation was 11.3 years (mean 9.9, range 0 to 15.9), 68% (15/22) were male and 77% (17/22) were ruptured on presentation. The majority of aneurysms were located at the anterior circulation (77% (17/22)). The overall median aneurysm size (n = 21) was 7.4 mm (mean 5 mm, range 2.5-19 mm). Twenty patients survived the acute phase and 80% (16/20) underwent coil embolisation and the other patients' surgical clipping. The overall outcomes were available for the 20 patients; on discharge, 90% (18/20) had a favourable clinical outcome (GOS score of 3-5). Treatment-specific clinical favourable outcomes were 88% (14/16) for coil embolisation against 100% (4/4) after surgical clipping. Of the two patients that died in the acute phase, one had sickle cell anaemia. Aneurysm aetiology was unknown in all other cases. None of the patients had a family history of aneurysms.

CONCLUSION:

Paediatric intracranial aneurysms while rare should be considered a differential diagnosis of children presenting with unexplained loss of consciousness with or without focal neurological deficit and/or headache. There is a two to one preponderance for males with a larger proportion of aneurysms within the posterior circulation (25%). Coil embolisation is the preferred method of securing a paediatric intracranial aneurysm.

KEYWORDS:

Delayed ischaemic neurological deficit; Endovascular coiling; Paediatric intracranial aneurysms; Subarachnoid haemorrhage; Surgical clipping

PMID:
31089852
DOI:
10.1007/s00381-019-04159-3

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center