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J Cell Physiol. 2019 May 13. doi: 10.1002/jcp.28777. [Epub ahead of print]

Natural flavonoids for the prevention of colon cancer: A comprehensive review of preclinical and clinical studies.

Author information

1
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4
Department of Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
5
Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, Palma de Mallorca, Spain.
6
CIBEROBN (Physiopathology of Obesity and Nutrition, CB12/03/30038), Instituto de Salud Carlos III, Madrid, Spain.
7
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, Iran.
8
Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
9
Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Abstract

Flavonoids comprise a group of natural polyphenols consisting of more than 5,000 subtypes mostly existing in fruits and vegetables. Flavonoids consumption could potentially attenuate the incidence and recurrence risk of colorectal cancers through their antiperoxidative, antioxidant, and anti-inflammatory effects. In addition, these compounds regulate the mitochondrial function, balance the bacterial flora and promote the apoptosis process in cancerous cells. However, some previous data failed to show the effectiveness of flavonoids in reducing the risk of colorectal cancer. In this study, we have reviewed the efficacy of different flavonoids subtypes on the risk of colon cancer and molecular mechanisms involved in this process in both clinical and animal studies. In addition, we tried to elucidate the potential synergy between these compounds and current colorectal cancer treatments.

KEYWORDS:

anti-inflammatory; antioxidant; colorectal cancer; flavonoids; supplement

PMID:
31087338
DOI:
10.1002/jcp.28777

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