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PeerJ. 2019 Apr 25;7:e6802. doi: 10.7717/peerj.6802. eCollection 2019.

Forensic characteristics and population genetics of Chinese Kazakh ethnic minority with an efficient STR panel.

Chen C1,2,3, Guo Y1,2,3, Jin X1,2,3, Cui W1,2,3, Wei Y1,2,3, Fang Y4, Lan Q4, Kong T1,2,3, Xie T4, Zhu B1,2,4.

Author information

1
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
2
Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
3
College of Medicine and Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, China.
4
Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China.

Abstract

On the purpose of enhancing the forensic efficiency of CODIS STR loci, new STR loci have been gradually discovered and developed into some commercial multiplex systems. Recently, 22 STR loci including 18 non-CODIS STR loci and four CODIS STR loci were investigated in 501 unrelated healthy individuals of Kazakh ethnic group. Seven to 20 alleles at the different loci were identified and altogether 276 alleles for 22 selected loci were detected with the corresponding allelic frequencies ranging from 0.0010 to 0.3623. No significant deviation was observed from the Hardy-Weinberg equilibrium test for any of the 22 STRs. The value of cumulative power of discrimination in Kazakh group was 1-1.00E-28. Analyses of population differentiations and genetic distances between Kazakh and other Chinese groups presented that the Kazakh group with the Uygur group. These 22 STR loci evenly distributed on 22 different autosomal chromosomes were characterized by high genetic diversities and therefore could be utilized in the forensic cases to further increase the discrimination performance.

KEYWORDS:

Chinese Kazakh; Forensic population genetics; Geneticpolymorphism; Non-CODIS STRs

Conflict of interest statement

The authors declare there are no competing interests.

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