Format

Send to

Choose Destination
Nat Rev Genet. 2019 May 13. doi: 10.1038/s41576-019-0128-0. [Epub ahead of print]

Long-range enhancer-promoter contacts in gene expression control.

Author information

1
Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, UK. stefan.schoenfelder@babraham.ac.uk.
2
Epigenetics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, UK. stefan.schoenfelder@babraham.ac.uk.
3
Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, UK.
4
Department of Biological Science, Florida State University, Tallahassee, FL, USA.

Abstract

Spatiotemporal gene expression programmes are orchestrated by transcriptional enhancers, which are key regulatory DNA elements that engage in physical contacts with their target-gene promoters, often bridging considerable genomic distances. Recent progress in genomics, genome editing and microscopy methodologies have enabled the genome-wide mapping of enhancer-promoter contacts and their functional dissection. In this Review, we discuss novel concepts on how enhancer-promoter interactions are established and maintained, how the 3D architecture of mammalian genomes both facilitates and constrains enhancer-promoter contacts, and the role they play in gene expression control during normal development and disease.

PMID:
31086298
DOI:
10.1038/s41576-019-0128-0

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center