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Neurol India. 2019 Mar-Apr;67(2):476-480. doi: 10.4103/0028-3886.258009.

The efficacy of gamma knife radiosurgery in patients with trigeminal neuralgia: The initial experience of the Bezmialem Vakif University.

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Department of Neurosurgery, Bezmialem Vakif University, Fatih, Istanbul, Turkey.



Gamma knife stereotactic radiosurgery is, compared with surgical treatment, a less invasive treatment option for patients with trigeminal neuralgia (TN).


In this report, we analyzed the effect and safety of gamma knife radiosurgery performed in patients with TN.

Materials and Methods:

We retrospectively reviewed patients who underwent gamma knife radiosurgery for TN between June 2014 and January 2017. All patients were treated with Leksell Gamma Knife Model C (Elekta, Stockholm, Sweden) with a prescription dose of 40 Gy with a 50% isodose line. The follow-up of the patients was performed 1 week after the procedure and after every 3 months. The pain score of the patients was recorded using the visual analog scale (VAS). Complications were also reviewed.

Statistical Analysis:

Statistical analysis was performed using the Statistical Package for the Social Sciences software for Windows, version 23.0.


Twenty-four patients (10 males, 14 females) were included in the study. The median age of the patients was 62.5 years (range, 34-91 years). The pre-gamma knife median VAS was 10 (range, 5-10), and the median VAS was 1 (range, 0-10) during the last follow-up. The pain decreased in 16 (76%) patients. Two patients (9%) had treatment-related complications. One patient developed hypoesthesia along the dermatome of the maxillary branch of the fifth cranial nerve and another patient developed facial paresis, which recovered after the usage of steroids for 3 months.


Gamma knife radiosurgery is an effective and safe treatment for patients with TN with an acceptable pain control rate.


Gamma Knife; stereotactic radiosurgery; trigeminal neuralgia


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