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J Lipid Res. 2019 Jul;60(7):1190-1198. doi: 10.1194/jlr.M089664. Epub 2019 May 13.

Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study.

Author information

1
Departments of Pharmaceutical Sciences University at Buffalo, The State University of New York, Buffalo, NY.
2
Biotechnical and Clinical Laboratory Sciences University at Buffalo, The State University of New York, Buffalo, NY.
3
Buffalo Neuroimaging Analysis Center, Department of Neurology The State University of New York, Buffalo, NY.
4
Jacobs Comprehensive Multiple Sclerosis Treatment and Research Center, Department of Neurology, The State University of New York, Buffalo, NY.
5
Center for Biomedical Imaging at Clinical Translational Science Institute Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY.
6
Departments of Pharmaceutical Sciences University at Buffalo, The State University of New York, Buffalo, NY Murali@Buffalo.Edu.

Abstract

The purpose of this work was to investigate whether changes in oxysterol and apolipoprotein levels over 5 years are associated with disease course and disability progression in multiple sclerosis (MS). This study included 139 subjects [39 healthy controls (HCs), 61 relapsing-remitting MS (RR-MS) patients, and 39 progressive MS (P-MS) patients]. Oxysterols [24-hydroxycholesterol (24HC), 25-hydroxycholesterol (25HC), 27-hydroxycholesterol (27HC), 7α-hydroxycholesterol (7αHC), and 7-ketocholesterol (7KC)] were measured at baseline and 5 years using a novel mass spectrometric method, and apolipoproteins were measured using immunoturbidometric diagnostic kits. Levels of 24HC (P = 0.004), 25HC (P = 0.029), and 27HC (P = 0.026) increased in P-MS patients. 7KC (P = 0.047) and 7αHC (P = 0.001) levels decreased in RR-MS patients, and there were no changes in any oxysterols in HCs. In MS patients, ApoC-II (all P ≤ 0.01) and ApoE (all P ≤ 0.01) changes were positively associated with all oxysterol levels. Increases in 24HC (P = 0.038) and ApoB (P = 0.038) and decreases in 7KC (P = 0.020) were observed in RR-MS patients who converted to secondary P-MS (SP-MS) at follow-up and in SP-MS patients compared with RR-MS patients. Oxysterols and their associations with apolipoproteins differed between MS patients and HCs over 5 years. Oxysterol and apolipoprotein changes were associated with conversion to SP-MS.

KEYWORDS:

cholesterol; disease progression; metabolism

PMID:
31085627
PMCID:
PMC6602132
[Available on 2020-07-01]
DOI:
10.1194/jlr.M089664

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