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Radiother Oncol. 2019 May 11;137:125-129. doi: 10.1016/j.radonc.2019.04.028. [Epub ahead of print]

In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field.

Author information

1
Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.
2
Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands; KVI Center for Advanced Radiation Technology, University of Groningen, The Netherlands.
3
Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands.
4
KVI Center for Advanced Radiation Technology, University of Groningen, The Netherlands.
5
Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.
6
Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.
7
Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands. Electronic address: r.p.coppes@umcg.nl.

Abstract

To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field does not modify the biological response.

KEYWORDS:

MRI; Normal tissue; Organoids; Protons; Tumor

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