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Trends Cell Biol. 2019 Aug;29(8):608-611. doi: 10.1016/j.tcb.2019.04.002. Epub 2019 May 10.

Probing Mechanical Properties in Biology Using Brillouin Microscopy.

Author information

1
Advanced Microscopy Facility, Vienna Biocenter Core Facilities, Vienna Biocenter (VBC), Dr Bohr-Gasse 3, 1030 Vienna, Austria. Electronic address: Kareem.Elsayad@vbcf.ac.at.
2
Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia; Department of Membrane Biochemistry, Institute of Animal Biochemistry and Genetics, Centre of Biosciences, Slovak Academy of Sciences, 84505 Bratislava, Slovakia.
3
Advanced Microscopy Facility, Vienna Biocenter Core Facilities, Vienna Biocenter (VBC), Dr Bohr-Gasse 3, 1030 Vienna, Austria; Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia; Department of Chromosome Biology, MFPL, University of Vienna, Vienna Biocenter (VBC), Dr Bohr-Gasse 9, 1030 Vienna, Austria. Electronic address: juraj.gregan@univie.ac.at.

Abstract

Brillouin microscopy can be used to map the mechanical properties of samples in a noncontact and label-free manner, with potential applications in cell biology. Here, we provide an overview of the underlying principles and technology as well as the current challenges and outlook.

KEYWORDS:

Brillouin microscopy; mechanical properties; mechanobiology; spectroscopy

PMID:
31085065
DOI:
10.1016/j.tcb.2019.04.002

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