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Bioresour Technol. 2019 May 6:121425. doi: 10.1016/j.biortech.2019.121425. [Epub ahead of print]

Acetone-free biobutanol production: Past and recent advances in the Isopropanol-Butanol-Ethanol (IBE) fermentation.

Author information

1
Laboratory of Optimization, Design, and Advanced Control - Fermentation Division (LOPCA-Ferm), School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, SP, Brazil.
2
Bioprocess and Metabolic Engineering Laboratory (LEMeB), School of Food Engineering, University of Campinas (UNICAMP), Campinas, SP, Brazil.
3
Laboratory of Optimization, Design, and Advanced Control - Fermentation Division (LOPCA-Ferm), School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: adpm@unicamp.br.

Abstract

Production of butanol for fuel via the conventional Acetone-Butanol-Ethanol fermentation has been considered economically risky because of a potential oversupply of acetone. Alternatively, acetone is converted into isopropanol by specific solventogenic Clostridium species in the Isopropanol-Butanol-Ethanol (IBE) fermentation. This route, although less efficient, has been gaining attention because IBE mixtures are a potential fuel. The present work is dedicated to reviewing past and recent advances in microorganisms, feedstock, and fermentation equipment for IBE production. In our analysis we demonstrate the importance of novel engineered IBE-producing Clostridium strains and cell retention systems to decrease the staggering number of fermentation tanks required by IBE plants equipped with conventional technology. We also summarize the recent progress on recovery techniques integrated with fermentation, especially gas stripping. In addition, we assessed ongoing pilot-plant efforts that have been enabling IBE production from woody feedstock.

KEYWORDS:

Advanced fermentation; Butanol; Feedstock; IBE fermentation; Metabolic engineering

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