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Plant Sci. 2019 Jul;284:67-72. doi: 10.1016/j.plantsci.2019.03.022. Epub 2019 Apr 4.

Terpenes in Cannabis sativa - From plant genome to humans.

Author information

1
Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, B.C., V6T 1Z4, Canada.
2
Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, B.C., V6T 1Z4, Canada. Electronic address: bohlmann@msl.ubc.ca.

Abstract

Cannabis sativa (cannabis) produces a resin that is valued for its psychoactive and medicinal properties. Despite being the foundation of a multi-billion dollar global industry, scientific knowledge and research on cannabis is lagging behind compared to other high-value crops. This is largely due to legal restrictions that have prevented many researchers from studying cannabis, its products, and their effects in humans. Cannabis resin contains hundreds of different terpene and cannabinoid metabolites. Many of these metabolites have not been conclusively identified. Our understanding of the genomic and biosynthetic systems of these metabolites in cannabis, and the factors that affect their variability, is rudimentary. As a consequence, there is concern about lack of consistency with regard to the terpene and cannabinoid composition of different cannabis 'strains'. Likewise, claims of some of the medicinal properties attributed to cannabis metabolites would benefit from thorough scientific validation.

KEYWORDS:

Cannabinoids; Cannabis; Entourage effect; Specialized secondary metabolism; Standardization; Strains; Terpene synthase; Terpenes

PMID:
31084880
DOI:
10.1016/j.plantsci.2019.03.022
[Indexed for MEDLINE]
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