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Mol Pharm. 2019 Jul 1;16(7):3109-3120. doi: 10.1021/acs.molpharmaceut.9b00342. Epub 2019 May 28.

Cellular Vehicles Based on Neutrophils Enable Targeting of Atherosclerosis.

Author information

1
State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Advanced Pharmaceuticals and Biomaterials , China Pharmaceutical University , No. 24 Tongjiaxiang , Nanjing 210009 , China.

Abstract

Given the multiple interactions between neutrophils (NEs) and atherosclerosis (AS), in this study, we exploited NEs as cellular vehicles loaded with cationic liposomes for actively targeting atherosclerotic sites. The cellular vehicles based on NEs possess efficient internalization of cationic liposomes and sensitive response to the chemotaxis of atherosclerotic inflammatory cells, which ultimately realize the targeted delivery of the cargos into the target cells in vitro. Moreover, these effects also translated to significant enhancement of the accumulation of NEs' cargos into the atherosclerotic plaque in vivo after administering NE vehicles to the AS animal model. Consequently, cellular vehicles based on NEs could be a novel strategy for targeted delivery of payloads into atherosclerotic plaque, which would facilitate theranostics for AS and the development of anti-AS drugs to manage the disease.

KEYWORDS:

atherosclerosis; cellular vehicles; inflammation; neutrophil; targeting delivery

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