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J Xray Sci Technol. 2019 May 7. doi: 10.3233/XST-180488. [Epub ahead of print]

A pilot study of radiomics technology based on X-ray mammography in patients with triple-negative breast cancer.

Author information

1
Department of Radiology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
2
Department of Radiology, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi, Jiangsu, China.

Abstract

PURPOSE:

To explore the radiomics features of triple negative breast cancer (TNBC) and non-triple negative breast cancer (non-TNBC) based on X-ray mammography, and to differentiate the two groups of cases.

MATERIALS AND METHODS:

Preoperative mammograms of 120 patients with breast ductal carcinoma confirmed by surgical pathology were retrospectively analyzed, which include 30 TNBC and 90 non-TNBC patients. The manual segmentation of breast lesions was performed by ITK-SNAP software and 12 radiomics features were extracted by Omni-Kinetics software. The differences of these radiomics features between TNBC and non-TNBC groups were compared, and the receiver operating characteristic (ROC) curve was used to determine the optimal cutoff value of each radiomics parameter for differentiating TNBC from non-TNBC, and the corresponding area under the curve (AUC), sensitivity and specificity were obtained.

RESULTS:

There were statistically significant differences for 4 radiomics features between TNBC and non-TNBC datasets (P <  0.05). They were the roundness, concavity, gray average and skewness of breast lesions. Compared with non-TNBC, TNBC cases have following characteristics of (1) more round with the roundness of 0.621 vs. 0.413 (P <  0.001), (2) more regular with the concavity of 0.087 vs. 0.141 (P <  0.01), (3) higher density or gray average (67.261 vs. 56.842, P <  0.05), and (4) lower skewness (- 0.837 vs.- 0.671, P = 0.034). AUCs of ROC curves computed using features of the roundness and concavity were both larger than 0.70.

CONCLUSION:

Radiomics features based on X-ray mammography may be helpful to distinguish between TNBC and non-TNBC, which were associated with breast tumor histology.

KEYWORDS:

Triple negative breast cancer; X-ray mammography; evaluation of tumor characteristics; quantitative imaging markers

PMID:
31081797
DOI:
10.3233/XST-180488

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