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Alzheimers Dement (Amst). 2019 Apr 16;11:327-332. doi: 10.1016/j.dadm.2019.02.004. eCollection 2019 Dec.

Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies.

Author information

1
Vita-Salute San Raffaele University, Milan, Italy.
2
In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
3
Nuclear Medicine Unit, San Raffaele Hospital, Milan, Italy.
4
European Institute for Molecular Imaging, University of Münster, Münster, Germany.
5
Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany.

Abstract

Introduction:

A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration," aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.

Methods:

We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques.

Results:

This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.

Discussion:

The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.

KEYWORDS:

Amyloid; Neuroinflammation; PET molecular imaging; Protheinopathies; Radiotracers; Tau

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