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Carbohydr Polym. 2019 Aug 1;217:152-159. doi: 10.1016/j.carbpol.2019.04.016. Epub 2019 Apr 6.

Novel injectable gallium-based self-setting glass-alginate hydrogel composite for cardiovascular tissue engineering.

Author information

1
DCU Biomaterials Research Group, Centre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, Dublin 9, Ireland.
2
DCU Biomaterials Research Group, Centre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, Dublin 9, Ireland; DUBBLE Beamline, European Synchrotron Radiation Facility (ESRF), 71 avenue des Martyrs, CS 40220, Grenoble, 38043, France; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: bing.wu@esrf.fr.
3
Vascular Biology and Therapeutic Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland.
4
School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
5
DUBBLE Beamline, European Synchrotron Radiation Facility (ESRF), 71 avenue des Martyrs, CS 40220, Grenoble, 38043, France; Department of Chemistry, KU Leuven, Celestijnenlaan 200F box 2404, 3001, Leuven, Belgium.
6
Department of Mechanical and Manufacturing Engineering, School of Engineering and Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland.

Abstract

Composite biomaterials offer a new approach for engineering novel, minimally-invasive scaffolds with properties that can be modified for a range of soft tissue applications. In this study, a new way of controlling the gelation of alginate hydrogels using Ga-based glass particles is presented. Through a comprehensive analysis, it was shown that the setting time, mechanical strength, stiffness and degradation properties of this composite can all be tailored for various applications. Specifically, the hydrogel generated through using a glass particle, wherein toxic aluminium is replaced with biocompatible gallium, exhibited enhanced properties. The material's stiffness matches that of soft tissues, while it displays a slow and tuneable gelation rate, making it a suitable candidate for minimally-invasive intra-vascular injection. In addition, it was also found that this composite can be tailored to deliver ions into the local cellular environment without affecting platelet adhesion or compromising viability of vascular cells in vitro.

KEYWORDS:

Alginate; Aneurysm; Cardiovascular; Glass; Polyalkenoate

PMID:
31079672
DOI:
10.1016/j.carbpol.2019.04.016
[Indexed for MEDLINE]

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