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Int J Surg Pathol. 2019 May 13:1066896919845478. doi: 10.1177/1066896919845478. [Epub ahead of print]

Perianal Goblet Cell Carcinoid With Pagetoid Spread.

Author information

1
1 Icahn School of Medicine at Mount Sinai, New York, NY, USA.
2
2 Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Abstract

We present a case of perianal goblet cell carcinoid with pagetoid spread. Goblet cell carcinoid, also known as adenocarcinoid tumor, predominantly arises as a primary appendiceal tumor and contains nests of neuroendocrine and mucin-containing cells. When this tumor type is seen in other sites it usually represents a metastasis. We present the case of an 81-year-old woman with a perianal mass. Histologic and immunohistochemical examination following surgical excision showed a goblet cell carcinoid demonstrating pagetoid spread along the perianal squamous mucosa. There was no evidence of a primary appendiceal tumor by history or imaging studies. To our knowledge, this is the first report of a goblet cell carcinoid presenting in this manner. The patient died due to complications of metastatic disease 26 months after initial diagnosis.

KEYWORDS:

goblet cell carcinoid; pagetoid spread; perianal

PMID:
31079516
DOI:
10.1177/1066896919845478

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