Format

Send to

Choose Destination
Neuroimage Clin. 2019 May 4;23:101851. doi: 10.1016/j.nicl.2019.101851. [Epub ahead of print]

Linked anatomical and functional brain alterations in children with attention-deficit/hyperactivity disorder.

Author information

1
Shenzhen Children's Hospital, China; Peking University Sixth Hospital, Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Nijmegen, the Netherlands. Electronic address: zhaomin.wu@foxmail.com.
2
Donders Institute for Brain, Cognition and Behavior, Nijmegen, the Netherlands.
3
Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Nijmegen, the Netherlands.
4
Peking University Sixth Hospital, Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
5
Shenzhen Children's Hospital, China.
6
Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.
7
Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
8
Peking University Sixth Hospital, Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China. Electronic address: wangyf@bjmu.edu.cn.

Abstract

OBJECTIVES:

Neuroimaging studies have independently demonstrated brain anatomical and functional impairments in participants with ADHD. The aim of the current study was to explore the relationship between structural and functional brain alterations in ADHD through an integrated analysis of multimodal neuroimaging data.

METHODS:

We performed a multimodal analysis to integrate resting-state functional magnetic resonance imaging (MRI), structural MRI, and diffusion-weighted imaging data in a large, single-site sample of children with and without diagnosis for ADHD. The inferred subject contributions were fed into regression models to investigate the relationships between diagnosis, symptom severity, gender, and age.

RESULTS:

Compared with controls, children with ADHD diagnosis showed altered white matter microstructure in widespread white matter fiber tracts as well as greater gray matter volume (GMV) in bilateral frontal regions, smaller GMV in posterior regions, and altered functional connectivity (FC) in default mode and fronto-parietal networks. Age-related growth of GMV of bilateral occipital lobe, FC in frontal regions as well as age-related decline of GMV in medial regions seen in controls appeared reversed in children with ADHD. In the whole group, higher symptom severity was related to smaller GMV in widespread regions in bilateral frontal, parietal, and temporal lobes, as well as greater GMV in intracalcarine and temporal cortices.

CONCLUSIONS:

Through a multimodal analysis approach we show that structural and functional alterations in brain regions known to be altered in subjects with ADHD from unimodal studies are linked across modalities. The brain alterations were related to clinical features of ADHD, including disorder status, age, and symptom severity.

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center