Current development of 5-nitrofuran-2-yl derivatives as antitubercular agents

Tilal Elsaman; Malik Suliman Mohamed; Magdi A Mohamed

doi:10.1016/j.bioorg.2019.102969

Current development of 5-nitrofuran-2-yl derivatives as antitubercular agents

Bioorg Chem. 2019 Jul:88:102969. doi: 10.1016/j.bioorg.2019.102969. Epub 2019 May 2.

Authors

Tilal Elsaman¹, Malik Suliman Mohamed², Magdi A Mohamed³

Affiliations

¹ Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University, Khartoum, Sudan. Electronic address: telbashir@ju.edu.sa.
² Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
³ Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.

PMID: 31077910
DOI: 10.1016/j.bioorg.2019.102969

Abstract

Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) and still remains one of the foremost fatal infectious diseases, infecting nearly a third of the worldwide population. The emergencies of multidrug-resistant and extensively drug-resistant tuberculosis (MDR and XDR-TB) prompt the efforts to deliver potent and novel anti-TB drugs. Research aimed at the development of new anti-TB drugs based on nitrofuran scaffold led to the identification of several candidates that were effective against actively growing as well as latent mycobacteria with unique modes of action. This review focuses on the recent advances in nitrofurans that could provide intriguing potential leads in the area of anti-TB drug discovery.

Keywords: 5-Nitrofuran; Structure-Activity Relationships (SARs); Tuberculosis (TB).

Publication types

Review

MeSH terms

Animals
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology*
Drug Discovery
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*
Nitrofurans / chemistry
Nitrofurans / pharmacology*
Tuberculosis, Pulmonary / drug therapy*

Substances

Antitubercular Agents
Nitrofurans