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J Magn Reson Imaging. 2019 May 11. doi: 10.1002/jmri.26781. [Epub ahead of print]

Ungated nonenhanced radial quiescent interval slice-selective (QISS) magnetic resonance angiography of the neck: Evaluation of image quality.

Author information

1
Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois, USA.
2
University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA.
3
Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Abstract

BACKGROUND:

Standard-of-care time-of-flight (TOF) techniques for nonenhanced magnetic resonance angiography (NEMRA) of the carotid bifurcation and other cervical arteries often provide nondiagnostic image quality due to motion and flow artifacts.

PURPOSE:

To perform an initial evaluation of an ungated radial quiescent-interval slice-selective (QISS) technique for NEMRA of the neck, in comparison with 2D TOF and contrast-enhanced magnetic resonance angiography (CEMRA).

STUDY TYPE:

Retrospective.

POPULATION:

Sixty patients referred for neck MR angiography.

FIELD STRENGTH/SEQUENCE:

Ungated radial QISS at 3T.

ASSESSMENT:

Three radiologists scored image quality of 18 arterial segments using a 4-point scale (1, nondiagnostic; 2, fair; 3, good; 4, excellent), and two radiologists graded proximal internal carotid stenosis using five categories (<50%, 50-69%, 70-99%, occlusion, nondiagnostic).

STATISTICAL TESTS:

Friedman tests with post-hoc Wilcoxon signed-rank tests; unweighted Gwet's AC1 statistic; tests for equality of proportions.

RESULTS:

Ungated radial QISS provided image quality that significantly exceeded 2D TOF (mean scores of 2.7 vs. 2.0, 2.7 vs. 2.2, and 2.9 vs. 2.3; P < 0.001, all comparisons), while CEMRA provided the best image quality (mean scores of 3.6, 3.7, and 3.5 for the three reviewers). Interrater agreement of image quality scores was substantial for CEMRA (AC1 = 0.70, P < 0.001), and moderate for QISS (AC1 = 0.43, P < 0.001) and TOF (AC1 = 0.41, P < 0.001). Compared with TOF, QISS NEMRA provided a significantly higher percentage of diagnostic segments for all three reviewers (91.0% vs. 71.7%, 93.5% vs. 72.9%, 95.5% vs. 85.2%; P < 0.0001) and demonstrated better agreement with CEMRA for grading of proximal internal carotid stenosis (AC1 = 0.94 vs. 0.73 for reviewer 1, P < 0.05; AC1 = 0.89 vs. 0.68 for reviewer 2, P < 0.05).

DATA CONCLUSION:

In this initial study, ungated radial QISS significantly outperformed 2D TOF for the evaluation of the neck arteries, with overall better image quality and more diagnostic arterial segments, and improved agreement with CEMRA for grading stenosis of the proximal internal carotid artery.

LEVEL OF EVIDENCE:

3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019.

KEYWORDS:

carotid bifurcation; magnetic resonance angiography; neck; nonenhanced; quiescent-interval slice-selective (QISS); time-of-flight

PMID:
31077477
DOI:
10.1002/jmri.26781

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