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Clin Infect Dis. 2019 May 11. pii: ciz389. doi: 10.1093/cid/ciz389. [Epub ahead of print]

Fatal Yellow Fever in a kidney transplant patient.

Author information

1
Infectious Diseases Division, Hospital das Clinicas, Universidade de São Paulo, São Paulo, Brazil.
2
Center for Clinical Research, Diagnósticos da América (DASA) Laboratory, São Paulo, SP, Brazil.
3
Pathology Department, Hospital das Clinicas, Universidade de São Paulo, São Paulo, Brazil.
4
LIM-37, Liver Transplantation Laboratory, Hospital das Clinicas, Universidade de São Paulo, São Paulo, Brazil.
5
Renal Transplantation Service, Hospital das Clinicas, Universidade de São Paulo, São Paulo, Brazil.

Abstract

A kidney transplanted patient, unvaccinated against yellow fever, developed high fever and progressed rapidly to hepatic insufficiency, coma and died eight days later. RT-PCR for YF virus collected on the 7th day of symptoms was positive. Autopsy showed disseminated infection and midzonal hepatitis with apoptotic hepatocytes, and minimal inflammatory reaction.

KEYWORDS:

kidney transplantation; organ transplantation; yellow fever; yellow fever vaccine

PMID:
31077273
DOI:
10.1093/cid/ciz389

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