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Laryngoscope. 2019 May 10. doi: 10.1002/lary.27902. [Epub ahead of print]

Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti-PD-1 Therapy.

Author information

1
Loyola University Chicago Stritch School of Medicine, Maywood, Illinois.
2
Department of Otolaryngology, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, University of Washington, Seattle, Washington.
3
Department of Medicine, Division of Medical Oncology, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, University of Washington, Seattle, Washington.
4
Department of Otolaryngology, Oregon Health and Sciences University, Portland, Oregon.
5
Department of Otolaryngology, Stanford University Medical Center, Palo Alto, California, U.S.A.

Abstract

Immune checkpoint inhibitors have demonstrated activity in recurrent/metastatic head and neck squamous cell cancer, but less is known regarding their long-term sequelae. We describe four patients who, after complete responses to anti-PD-1 therapy, developed complications requiring surgical intervention. Patient 1 is a 57-year-old female whose marked tumor regression exposed some mandibular hardware. Patient 2 is a 39-year-old male who developed an ulcerated buccal lesion with exposed mandible. Patient 3 is a 66-year-old male with craniofacial osteoradionecrosis. Patient 4 is a 71-year-old male who developed an exposed and fractured mandible. All patients successfully underwent surgical intervention and remain disease free. Laryngoscope, 2019.

KEYWORDS:

Head and neck cancer; checkpoint inhibitors; head and neck squamous cell carcinoma; immunotherapy; monoclonal antibodies; osteoradionecrosis

PMID:
31074843
DOI:
10.1002/lary.27902

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