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J Neurooncol. 2019 May 9. doi: 10.1007/s11060-019-03186-z. [Epub ahead of print]

Health-related quality of life of patients with brain metastases selected for stereotactic radiosurgery.

Author information

1
Gamma Knife Center, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.
2
Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.
3
Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands.
4
Gamma Knife Center, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands. k.gehring@tilburguniversity.edu.
5
Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands. k.gehring@tilburguniversity.edu.
6
Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands. k.gehring@tilburguniversity.edu.

Abstract

PURPOSE:

Information on health-related quality of life (HRQoL) of patients with brain metastases (BM) before stereotactic radiosurgery (SRS) is very relevant to improve communication between patients and clinicians and to be able to interpret changes in HRQoL after SRS. The aim of this study was to evaluate the prevalence and severity of complaints on different aspects of pre-SRS HRQoL among patients with BM and to identify predictors thereof.

METHODS:

Patients with 1-10 newly diagnosed BM, expected survival > 3 months, Karnofsky Performance Status ≥ 70, and scheduled to undergo SRS were included. HRQoL was measured with the Functional Assessment of Cancer Therapy-Brain (FACT-Br) questionnaire. One-sample z-tests were conducted to analyze differences between patients with BM and published normative data of a general adult sample and of an adult cancer sample. Multiple regression analyses were run to identify predictors of pre-SRS HRQoL.

RESULTS:

On the individual level, most patients with BM (57.6% of 92 included patients) reported complaints regarding emotional well-being. As a group, patients with BM reported significantly lower emotional well-being compared to both control groups and significantly higher social well-being compared to the general population. Worse psychological factors, e.g. physical fatigue, depression, mental fatigue and anxiety, predicted aspects of pre-SRS HRQoL.

CONCLUSIONS:

An increased understanding of pre-SRS HRQoL and predictors hereof, provides us with more insight into the well-being of our patients with BM and is necessary for the interpretation of (changes in) HRQoL after SRS.

KEYWORDS:

Brain metastases; Cancer; Gamma knife radiosurgery; Health-related quality of life; Patient-reported outcome measures; Radiosurgery

PMID:
31073966
DOI:
10.1007/s11060-019-03186-z

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