Format

Send to

Choose Destination
Org Biomol Chem. 2019 May 28;17(20):5148-5152. doi: 10.1039/c9ob00531e. Epub 2019 May 10.

Selective synthesis of (1H-benzo[d]imidazol-2-yl)(phenyl)methanone and quinoxaline from aromatic aldehyde and o-phenylenediamine.

Author information

1
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, P. R. China. hgs@lzu.edu.cn.

Abstract

We have designed a general, inexpensive, and versatile method for the synthesis of (1H-benzo[d]imidazol-2-yl)(phenyl)methanone and the formation of C-N bonds via an aromatic aldehyde and o-phenylenediamine. In the presence of N,N-dimethylformamide/sulfur, (1H-benzo[d]imidazol-2-yl)(phenyl)methanone was obtained; however, in the absence of sulfur, quinoxaline was obtained in 1,4-dioxane. A wide range of quinoxalines and (1H-benzo[d]imidazol-2-yl)(phenyl)methanones was obtained under mild conditions.

PMID:
31073576
DOI:
10.1039/c9ob00531e

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center