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Trends Pharmacol Sci. 2019 Jun;40(6):362-364. doi: 10.1016/j.tips.2019.04.010. Epub 2019 May 6.

Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics.

Author information

1
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel. Electronic address: ofer.yizhar@weizmann.ac.il.
2
Research Group Synaptic Wiring and Information Processing, Center for Molecular Neurobiology Hamburg, Falkenried 94, 20251 Hamburg, Germany. Electronic address: simon.wiegert@zmnh.uni-hamburg.de.

Abstract

Chemogenetic techniques allow selective manipulation of neurons by activating engineered actuator proteins with otherwise inert effector molecules. A recent study (Magnus et al. Science 2019;364:eaav5282) describes the coevolution of highly potent actuator-effector pairs based on a clinically approved antismoking drug. These tools allow selective excitation or inhibition of neurons in the living brain with high specificity and no detectable side-effects.

KEYWORDS:

chemogenetics; drug design; gene therapy; neuromodulation

PMID:
31072638
PMCID:
PMC6548557
[Available on 2020-06-01]
DOI:
10.1016/j.tips.2019.04.010

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