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Nanomaterials (Basel). 2019 May 8;9(5). pii: E713. doi: 10.3390/nano9050713.

Antibacterial Application on Staphylococcus aureus Using Antibiotic Agent/Zinc Oxide Nanorod Arrays/Polyethylethylketone Composite Samples.

Chen DW1,2, Lee KY3,4, Tsai MH5,6, Lin TY7,8, Chen CH9,10, Cheng KW11,12.

Author information

1
Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Keelung Branch, Taoyuan 204, Taiwan. mr5181@adm.cgmh.org.tw.
2
College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. mr5181@adm.cgmh.org.tw.
3
Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Keelung Branch, Taoyuan 204, Taiwan. m0423042@stmail.cgu.edu.tw.
4
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 333, Taiwan. m0423042@stmail.cgu.edu.tw.
5
Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Keelung Branch, Taoyuan 204, Taiwan. m0523048@stmail.cgu.edu.tw.
6
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 333, Taiwan. m0523048@stmail.cgu.edu.tw.
7
Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Keelung Branch, Taoyuan 204, Taiwan. ross_1222@hotmail.com.
8
College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. ross_1222@hotmail.com.
9
Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Keelung Branch, Taoyuan 204, Taiwan. chchen1982@gmail.com.
10
College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. chchen1982@gmail.com.
11
Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Keelung Branch, Taoyuan 204, Taiwan. kwcheng@mail.cgu.edu.tw.
12
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 333, Taiwan. kwcheng@mail.cgu.edu.tw.

Abstract

In this study, zinc oxide (ZnO) nanorod arrays as antibiotic agent carriers were grown on polyetheretherketone (PEEK) substrates using a chemical synthesis method. With the concentration of ammonium hydroxide in the precursor solution kept at 4 M, ZnO nanorod arrays with diameters in the range of 100-400 nm and a loading density of 1.7 mg/cm2 were grown onto the PEEK substrates. Their drug release profiles and the antibacterial properties of the antibiotic agent/ZnO/PEEK samples in the buffer solution were investigated. The results showed that the concentrations of antibiotic agents (ampicillin or vancomycin) released from the samples into the buffer solution were higher than the value of minimum inhibitory concentration of 90% for Staphylococcus aureus within the 96 h test. The bioactivities of ampicillin and vancomycin on substrates also showed around 40% and 80% on the Staphylococcus aureus, respectively. In the antibacterial activity test, sample with the suitable loading amount of antibiotic agent had a good inhibitory effect on the growth of Staphylococcus aureus.

KEYWORDS:

antibacterial properties; nanorods; polyetheretherketone (PEEK); zinc oxide

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