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Int J Mol Sci. 2019 May 8;20(9). pii: E2263. doi: 10.3390/ijms20092263.

Circadian Regulation in Tissue Regeneration.

Author information

1
Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA. paate001@umn.edu.
2
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. paate001@umn.edu.
3
Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA. munso220@umn.edu.
4
Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA. kikyo001@umn.edu.
5
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. kikyo001@umn.edu.

Abstract

Circadian rhythms regulate over 40% of protein-coding genes in at least one organ in the body through mechanisms tied to the central circadian clock and to cell-intrinsic auto-regulatory feedback loops. Distinct diurnal differences in regulation of regeneration have been found in several organs, including skin, intestinal, and hematopoietic systems. Each regenerating system contains a complex network of cell types with different circadian mechanisms contributing to regeneration. In this review, we elucidate circadian regeneration mechanisms in the three representative systems. We also suggest circadian regulation of global translational activity as an understudied global regulator of regenerative capacity. A more detailed understanding of the molecular mechanisms underlying circadian regulation of tissue regeneration would accelerate the development of new regenerative therapies.

KEYWORDS:

circadian rhythms; hematopoiesis; intestine; ribosome biogenesis; skin; tissue regeneration

PMID:
31071906
PMCID:
PMC6539890
DOI:
10.3390/ijms20092263
[Indexed for MEDLINE]
Free PMC Article

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