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Korean J Fam Med. 2019 May 9. doi: 10.4082/kjfm.18.0067. [Epub ahead of print]

Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study.

Author information

1
Department of Internal Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2
Department of Psychiatry, Substance Abuse Prevention Research Center, Health institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3
Department of Gynecology and Obstetrics, Kermanshah University Of Medical Sciences, Kermanshah, Iran.

Abstract

Background:

Menopausal symptoms have remarkable negative effects on women's quality of life, justifying the need to assess various therapeutic options. This research aimed to determine the effectiveness of Vitex agnus-castus extracts in alleviating menopausal symptoms in comparison with that of placebo.

Methods:

This study was a randomized controlled double-blind clinical trial with a study group of 52 women referred to a clinic in Kermanshah in 2017. The participants were randomly divided into two groups: Vitex group (26 subjects) and placebo group (26 subjects). Menopausal symptoms were assessed using the Greene Scale before and 8 weeks after the intervention.

Results:

After the intervention, the mean scores for total menopausal disorder, anxiety, and vasomotor dysfunction were significantly lower in the Vitex group than in the placebo group (P<0.05). The mean scores of the variables of somatic complications, depression, and sexual dysfunction did not show significant differences between the Vitex and placebo groups (P>0.05).

Conclusion:

Administration of Vitex agnus-castus extracts as a phytoestrogenic medicine can alleviate menopausal symptoms in women.

KEYWORDS:

Menopause; Placebo Effect; Vitex agnus-castus Extract; Women

PMID:
31067851
DOI:
10.4082/kjfm.18.0067
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