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Allergy. 2019 May 8. doi: 10.1111/all.13855. [Epub ahead of print]

Do NERDy eosinophils accelerate nasal polyp growth?

Author information

1
Department of Otolaryngology, Head and Neck Surgery, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
2
Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Abstract

Since its description by Widal in 1922 and Max Samter in 1967, significant efforts have been made to understand the molecular underpinnings of NSAID-exacerbated respiratory disease (NERD), which comprises the pathognomonic triad of asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and respiratory sensitivity to NSAID ingestion.[1] An intriguing aspect of this syndrome is that it is typically acquired in adulthood and only a minority of patients with nasal polyps, asthma or both conditions has sensitivity to NSAIDs. These observations would suggest the pathogenesis is neither a germ line metabolic syndrome nor a synergistic systemic manifestation of the component respiratory ailments. This article is protected by copyright. All rights reserved.

PMID:
31067351
DOI:
10.1111/all.13855

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