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Artif Organs. 2019 May 8. doi: 10.1111/aor.13485. [Epub ahead of print]

Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients.

Author information

1
Baqiyatallah University of Medical Sciences, Nanobiotechnology Research Center, Tehran, Iran.
2
Tehran University of Medical Sciences, Medical Nanotechnology, medical nanotechnology tehran university, italy street, tehran, iran.
3
Shahid Beheshti University of Medical Sciences School of Rehabilitation, Department of Physiotherapy, Tehran.
4
School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Department of Physiotherapy, Tehran.
5
Baqiyatallah University of Medical Sciences, Nanobiotechnology Research Center, Tehran.
6
Tehran University of Medical Sciences, Medical Nanotechnology, Tehran.

Abstract

The world population is ageing at an alarming rate, currently increasing at around 3% per year for people over 60 years. This fast growing demography is largely unproductive and prone to many brain disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and brain tumors. Currently available treatment modalities are inadequate to stop neural degeneration or to completely eradicate cancer cells. Exogenously engineered scaffolds hold great potential for in vivo brain regeneration and functional restoration. Ideally, scaffolds for brain tissue engineering should be biocompatible, non-toxic and electroactive with the ability to encourage neural elongation. These scaffolds have been successfully fabricated from a wide range of materials and techniques. Different types of stem cells have also been investigated for their ability to differentiate to nerve or glial tissue. The success of tissue engineering can thus be envisioned as a panacea for "retooling" of both individual's ability and national labour. This article is protected by copyright. All rights reserved.

KEYWORDS:

Alzheimer's disease; Parkinson's disease; Tissue engineering; scaffold

PMID:
31066912
DOI:
10.1111/aor.13485

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