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Arch Virol. 2019 Jul;164(7):1761-1770. doi: 10.1007/s00705-019-04260-7. Epub 2019 May 7.

Hepatitis C virus 3b strains in injection drug users in Guangdong Province, China, may have originated in Yunnan Province.

Wang M1,2, Liao Q1,2, Xu R1,2, Song D1,3, Huang J1,2, You Q4, Shan Z1,2, Huang K1,2, Rong X5,6,7, Fu Y8,9,10.

Author information

1
Guangzhou Blood Center, 31 Lu Yuan Road, Guangzhou, 510095, Guangdong, China.
2
The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
3
The Fifth People's Hospital of Zhuhai, Guangdong, China.
4
School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China.
5
Guangzhou Blood Center, 31 Lu Yuan Road, Guangzhou, 510095, Guangdong, China. joyjoy@126.com.
6
The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China. joyjoy@126.com.
7
School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China. joyjoy@126.com.
8
Guangzhou Blood Center, 31 Lu Yuan Road, Guangzhou, 510095, Guangdong, China. fuyongshui1969@yahoo.com.
9
The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China. fuyongshui1969@yahoo.com.
10
School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China. fuyongshui1969@yahoo.com.

Abstract

The distribution of hepatitis C virus (HCV) genotypes/subtypes varies among different populations. Here, we investigated HCV infection and its genotype distribution in injection drug users (IDUs) in Guangdong Province of China. A total of 318 IDUs from two prisons were recruited. The genotypes/subtypes of HCV in IDUs were determined by phylogenetic analysis using E1 and/or NS5B gene sequences. Our previous data on blood donors (BDs) with no history of drug use were used as control population data for comparison. Our results showed that the prevalence of HCV 3b (20.9% vs. 3.6%, P = 3.4E-9) and 6a (57.0% vs. 39.8%, P = 1.2E-5) was higher in IDUs than in BDs. In contrast, the prevalence of HCV 1b (43.4% vs. 5.6%, P = 9.8E-23) in BDs was higher than in IDUs. Phylogeographic analysis indicated that HCV 3b migrated from Yunnan to Guangdong Province and became endemic, with further transmission to other regions of China. The trend of HCV 3b dissemination in China in IDUs requires further attention, and a strategy for prevention and therapy is needed.

PMID:
31065852
DOI:
10.1007/s00705-019-04260-7

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