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Graefes Arch Clin Exp Ophthalmol. 2019 Aug;257(8):1751-1758. doi: 10.1007/s00417-019-04330-1. Epub 2019 May 7.

Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies.

Author information

1
Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Nishi 7, Kita 15, Kita-ku, Sapporo, 060-8638, Japan.
2
Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Nishi 7, Kita 15, Kita-ku, Sapporo, 060-8638, Japan. wsaito@med.hokudai.ac.jp.
3
Kaimeido Eye and Dental Clinic, Sapporo, Japan. wsaito@med.hokudai.ac.jp.

Abstract

PURPOSE:

To compare the clinical characteristics of Vogt-Koyanagi-Harada (VKH) disease patients with and without anti-retinal antibodies (ARAs) that are frequently detected in autoimmune retinopathy.

METHODS:

Using immunoblot analyses, serum autoantibodies for recoverin, carbonic anhydrase II, and α-enolase were examined in 20 treatment-naïve patients with VKH disease. Clinical factors before and after systemic corticosteroid therapy, including best-corrected visual acuity (BCVA) and macular outer retinal morphology, were statistically compared between patients with VKH disease with and without ARAs.

RESULTS:

Serum ARAs were detected in 50.0% of patients with VKH disease. There were no significant differences in clinical factors between the two groups, including final BCVA, frequency of uveitis recurrence, and recovery of the macular ellipsoid zone after systemic corticosteroid therapy.

CONCLUSIONS:

Our results suggest that the detected ARAs did not influence visual outcomes, the chronicity of uveitis, or outer retinal morphology in patients with VKH disease.

KEYWORDS:

Anti-retinal antibodies; Carbonic anhydrase II; Recoverin; Vogt-Koyanagi-Harada disease; α-Enolase

PMID:
31065846
DOI:
10.1007/s00417-019-04330-1
[Indexed for MEDLINE]

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