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Biomed Opt Express. 2018 Nov 2;9(12):5903-5914. doi: 10.1364/BOE.9.005903. eCollection 2018 Dec 1.

Scattering-independent glucose absorption measurement using a spectrally resolved reflectance setup with specialized variable source-detector separations.

Liu J1,2, Zhu C3,2, Jiang J4,5,6, Xu K1,5,7.

Author information

1
State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin, China.
2
These authors contributed equally to this work.
3
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
4
Paul C Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
5
These senior authors contributed equally to this work.
6
jy.jiang@siat.ac.cn.
7
kexin@tju.edu.cn.

Abstract

We report a novel approach for the accurate measurement of glucose absorption in turbid media using a spectrally resolved reflectance setup. Our proposed reflectance setup with specialized variable source-detector separations enables scattering-independent absorption measurement, which is critical to in vivo long-term glucose concentration monitoring. Starting from the first-order approximation of the radiative transfer equation (RTE), we developed a scattering-independent glucose absorption measurement method and then evaluated this approach by Monte Carlo simulations as well as tissue-mimicking phantom studies in which glucose concentration was accurately measured. Our study demonstrates the potential of our proposed scattering-independent absorption measurement technique as an effective tool to quantify glucose levels in turbid media, which is an important step towards future in vivo long-term glucose concentration monitoring in human subjects.

Conflict of interest statement

The authors declare that there are no known conflicts of interest related to this article.

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