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Int J Mol Sci. 2019 May 6;20(9). pii: E2214. doi: 10.3390/ijms20092214.

Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans.

Author information

1
Division of Preventive Medicine, National Hospital Organization Kyoto Medical Center, Clinical Research Institute, Kyoto 612-8555, Japan. shi.nirengi@gmail.com.
2
Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. fuse@tokyo-med.ac.jp.
3
Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo 160-8402, Japan. shiho.ama@gmail.com.
4
Faculty of Sports and Health Science, Daito Bunka University, Higashimatsuyama-shi, Saitama 355-8501, Japan. t-homma@ic.daito.ac.jp.
5
Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. kime@tokyo-med.ac.jp.
6
Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. mkuroiwa@tokyo-med.ac.jp.
7
Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. endo-tasuki-fv@ynu.jp.
8
Division of Preventive Medicine, National Hospital Organization Kyoto Medical Center, Clinical Research Institute, Kyoto 612-8555, Japan. nsakane@gf6.so-net.ne.jp.
9
Department of Nutrition, Tenshi College, Sapporo 065-0013, Japan. matsushita@tenshi.ac.jp.
10
Hokkaido University, Sapporo 060-0818, Japan. ms-consa@krf.biglobe.ne.jp.
11
Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. yuko.kurosawa.2011@gmail.com.
12
Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. kyp02504@nifty.com.

Abstract

Brown adipose tissue (BAT) may potentially be used in strategies for preventing lifestyle-related diseases. We examine evidence that near-infrared time-resolved spectroscopy (NIRTRS) is capable of estimating human BAT density (BAT-d). The parameters examined in this study are total hemoglobin [total-Hb]sup, oxygenated Hb [oxy-Hb]sup, deoxygenated Hb [deoxy-Hb]sup, Hb O2 saturation (StO2sup), and the reduced scattering coefficient in the supraclavicular region (μs'sup), where BAT deposits can be located; corresponding parameters in the control deltoid region are obtained as controls. Among the NIRTRS parameters, [total-Hb]sup and [oxy-Hb]sup show region-specific increases in winter, compared to summer. Further, [total-Hb]sup and [oxy-Hb]sup are correlated with cold-induced thermogenesis in the supraclavicular region. We conclude that NIRTRS-determined [total-Hb]sup and [oxy-Hb]sup are useful parameters for evaluating BAT-d in a simple, rapid, non-invasive manner.

KEYWORDS:

18F-fluorodeoxyglucose-positron emission tomography; brown adipose tissue (BAT); cold-induced thermogenesis; noninvasive; seasonal temperature fluctuations; thermogenic functional ingredients

PMID:
31064052
DOI:
10.3390/ijms20092214
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