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Dev Cell. 2019 May 6;49(3):304-305. doi: 10.1016/j.devcel.2019.04.025.

ALK7 Erects a Suppressive Barrier to Tumor Progression and Metastasis.

Author information

1
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: venturaa@mskcc.org.

Abstract

Overcoming intrinsic and extrinsic tumor-suppressive barriers is an essential feature of tumor progression. In this issue of Developmental Cell, Michael et al. (2019) use the RIP-Tag mouse model to show that pro-apoptotic signals mediated by the Activin B-ALK7 axis suppress ectopic proliferation and metastasis during pancreatic neuroendocrine cancer development.

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