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Arch Argent Pediatr. 2019 Jun 1;117(3):143-148. doi: 10.5546/aap.2019.eng.143.

Thiol-disulphide homeostasis is an oxidative stress indicator in critically ill children with sepsis.

[Article in English, Spanish; Abstract available in Spanish from the publisher]

Author information

1
Universidad de Ciencias de la Salud, Hospital de Formación e Investigación en Salud Infantil y Enfermedades Pediátricas, Hematología y Oncología, Ankara, Turquía. ganimeayar@gmail.com.
2
Universidad de Ciencias de la Salud, Hospital de Formación e Investigación Materno Infantil Dr. Sami Ulus, Ankara, Turquía.
3
Universidad de Ciencias de la Salud, Hospital de Formación e Investigación en Salud Infantil y Enfermedades Pediátricas, Hematología y Oncología, Ankara, Turquía.
4
Yildirim Beyazit Üniversitesi, Hospital de Formación e Investigación de Ankara Atatürk, Departamento de Bioquímica, Ankara, Turquía.

Abstract

in English, Spanish

The aim of this study is to evaluate a novel oxidative stress marker (thiol-disulphide homeostasis) in paediatric sepsis and to determine their effects on the prognosis of sepsis. Patients diagnosed with sepsis (n= 38) and healthy controls (n= 40) were incorporated in the study. Total thiol, native thiol, disulphide, disulphide/total thiol, disulphide/native thiol, and native thiol /total thiol levels were measured in the sepsis and control groups. Additionally, the parameters were compared between survivors and non-survivors in the sepsis group. The levels of hemoglobin, white blood cell, platelet, lactate, and C-reactive protein were measured in patients with sepsis at diagnosis. The paediatric risk of mortality and paediatric logistic organ dysfunction scores of the patients were used to estimate the disease severity. The plasma thiol levels of the patients with sepsis were significantly lower than the control group (p < 0.001). This study showed that thiol/disulphide homeostasis is abnormal in children with sepsis in Paediatric Intensive Care Unit.

KEYWORDS:

Child; Homeostasis; Oxidative stress; Sepsis; Thiol-disulphide

PMID:
31063297
DOI:
10.5546/aap.2019.eng.143
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Conflict of interest statement

The authors report no conflicts of interest in this work.

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