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Diabetes Metab Res Rev. 2019 May 6:e3175. doi: 10.1002/dmrr.3175. [Epub ahead of print]

Decreased heart rate variability as a predictor for diabetes-A prospective study of the Brazilian longitudinal study of adult health.

Author information

1
Center for Clinical and Epidemiological Research of University Hospital, University of Sao Paulo, Sao Paulo, SP, Brazil.
2
Department of Biological Sciences, Federal University of Vale do Sao Francisco, Petrolina, PE, Brazil.
3
Department of Electrical Engineering, Federal Institute of Espirito Santo, Vitoria, ES, Brazil.
4
Postgraduate Programme in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
5
Department of Social Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
6
Department of Physiological Sciences, Federal University of Espírito Santo, Vitoria, ES, Brazil.

Abstract

AIM:

To investigate whether heart rate variability (HRV) is a predictor for the incidence of diabetes in a 4-year follow-up.

MATERIALS AND METHODS:

The HRV of 9192 participants free of diabetes was analysed in time and frequency domains and stratified based on the reference values presented in the literature. The participants were then allocated to one of three groups, according to age-specific value distributions for each HRV domain: lower than the 25th percentile, between the 25th and 75th percentiles, and higher than the 75th percentile. The association between HRV and diabetes incidence at 4-year follow-up was analysed using Poisson regression models with robust estimator.

RESULTS:

Six hundred thirty-four participants (6.90%) developed diabetes within 4 years and five out of six HRV analysed indices showed increased relative risk of developing diabetes associated with low HRV: SDNN (RR = 1.29; 95% CI, 1.09-1.52; .003), pNN50 (RR = 1.33; 95% CI, 1.11-1.58; .001), RMSSD (RR = 1.29; 95% CI, 1.09-1.53; .004), LF (RR = 1.25; 95% CI, 1.05-1.48; .012), and HF (RR = 1.39; 95% CI, 1.16-1.63; .001).

CONCLUSIONS:

This study suggests that both overall variability and changes in parasympathetic modulation precede the incidence of diabetes. For four HRV indices below the 25th percentile, the risk for incident diabetes was 68% higher than for those participants who presented none. We concluded that HRV is an independent risk predictor of diabetes in a 4-year period.

KEYWORDS:

autonomic nervous system; incidence; parasympathetic function; predictors; sympathetic nervous system

PMID:
31062488
DOI:
10.1002/dmrr.3175

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