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Ginekol Pol. 2019;90(4):217-222. doi: 10.5603/GP.2019.0039.

Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy.

Author information

1
Obstetrics and Gynecology, Samsun Research and Education Hospital, Turkey.
2
Ondokuz Mayıs University, Department of Obstetrics and Gynecology, Turkey. drhandancelik@hotmail.com.
3
Pendik Training and Research Hospital, Department of Obstetrics and Gynecology, Turkey.
4
Düzce University, Department of Obstetrics and Gynecology, Turkey.

Abstract

OBJECTIVES:

Our objective was to evaluate in our clinic the perinatal outcomes of patients diagnosed with ICP based on pre-treatment maternal serum bile acid levels, attempt to identify the risk group and review the literature in light of this information.

MATERIAL AND METHODS:

In total, 370 patients diagnosed with ICP were included in the study, divided into two groups based on the fasting total serum bile acid level before UDCA (Group 1: 10 ≥ 40 μmol/L, and Group 2: ≥ 40 μmol/L). The groups were examined for clinical characteristics and pregnancy outcomes.

RESULTS:

It was found that preterm delivery and neonatal intensive care need increased at a serum bile acid cut-off value of 34 μmol/L. Regardless of serum bile acid, significantly higher rates of meconium-stained amniotic fluid and foetal distress were observed in patients whose diagnoses were made before 34 weeks of gestation.

CONCLUSIONS:

Foetal complications over 40 μmol/L of serum bile acid were significantly increased. However, slightly lower levels cut-off values (34 μmol/L) were obtained in terms of preterm birth and neonatal intensive care need. The incidence of meconium-stained amniotic fluid and foetal distress was higher in patients whose diagnosis were made before 34 weeks of gestation.

KEYWORDS:

intrahepatic cholestasis; perinatal complications; pregnancy

PMID:
31059115
DOI:
10.5603/GP.2019.0039
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