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Ginekol Pol. 2019;90(4):201-205. doi: 10.5603/GP.2019.0036.

Short-term dexamethasone plus acetylsalicylic acid treatment during in vitro fertilization procedure.

Author information

1
Gynecology and Obstetrics Clinic, Clinical Center Nis, Faculty of Medicine, University of Nis, Serbia.
2
Department of Pathophysiology, Faculty of Medicine, University of Nis, Serbia. jelenaradovic982@gmail.com.
3
Department of Pathophysiology, Faculty of Medicine, University of Nis, Serbia.
4
Faculty of Medicine, University of Nis, Serbia.

Abstract

OBJECTIVES:

Embryo implantation represents the major limiting step during in vitro fertilization (IVF) procedure. Immu- nological and coagulation abnormalities were shown to have a substantial part in multifactorial etiology of IVF failure. We aimed to investigate the effect of short-term low-dose dexamethasone plus acetylsalicylic acid (ASA) treatment, starting at the time of embryo transfer, on the implantation and clinical pregnancy rates in general IVF population.

MATERIAL AND METHODS:

Out of 233 consecutive patients undergoing fresh IVF/intracytoplasmic sperm injection (ICSI) cycles 64 received an adjuvant treatment consisting of dexamethasone (0.5 mg/day) plus ASA (100 mg/day) (DA group), starting on the day of embryo transfer. Patients not receiving these medications comprised a control group.

RESULTS:

Significantly more patients in DA group had positive ß-hCG values than controls (59.38% vs. 37.67%, p = 0.004) (OR = 2.42, 95% CI: 1.33-4.41). Implantation rate was 26.53% in DA group and 15.92% in controls (p = 0.0294). Clinical preg- nancy rate per started cycle was higher in DA group (43.59%) than controls (28.92%), but the difference was not significant (p = 0.0879; OR = 1.99, 95% CI: 0.89-4.41).

CONCLUSIONS:

Our study shows a potential benefit of dexamethasone plus ASA adjuvant treatment in females undergoing IVF/ICSI procedure. As these results show improvement of IVF outcome, a greater number of patients undergoing this type and regime of adjuvant treatment should be investigated.

KEYWORDS:

assisted reproductive techniques; coagulation disorders; embryo implantation; glucocorticoid effects; pregnancy rate; spontaneous abortion

PMID:
31059112
DOI:
10.5603/GP.2019.0036
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