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J Oncol Res Ther. 2017;3(4). pii: 132. Epub 2017 Sep 25.

Oral Squamous Cell Carcinomas are Associated with Poorer Outcome with Increasing Ages.

Lubpairee T1,2, Poh CF1,3,4, Laronde DM1,2,3, Rosin MP3,4,5, Zhang L1,2,3.

Author information

1
Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia (BC), Vancouver, Canada.
2
BC Oral Cancer Prevention Program, BC Cancer Agency, Vancouver, Canada.
3
BC Oral Biopsy Service, Vancouver General Hospital, Vancouver, Canada.
4
BC Cancer Research Centre, Vancouver, Canada.
5
School of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.

Abstract

Objectives:

1.1.Although oral cancers traditionally occur in people between the age of 50 and 70, there are increasing incidences of this disease in younger and very old people. Objectives: to compare the demographics, habits, clinicopathological features, treatment and outcome of oral cancer in three age groups of patients: Young (≤ 45), Traditional (46 to 75), and Old (> 75).

Subjects:

1.2.Primary oral cancers (393 patients) in a longitudinal study were used.

Results:

1.3.Significant differences were noted in ethnicity (fewer Caucasian patients in Young), tobacco habit (more non-smokers in Young), location of cancer (more at tongue for Young and more at low-risk sites for Old) and treatment (more surgery for Young). Compared to Young (univariate analysis), Traditional and Old showed a 3- and 4.5-fold increase in local recurrences respectively; 1.9- and 2.7-fold increase in regional metastasis; 3.1- and 5.4-fold increase in death due to disease; and a 3.4- and 6.6-fold decrease in overall survival. Compared to Young (multivariate analysis), Traditional and Old showed a 2.4- and 3.3-fold increase in local recurrence; 2.7- and 5.4-fold increase in disease-specific survival; and 2.8- and 6.5-fold decrease in overall survival.

Conclusion:

1.4.Oral cancer in different age groups showed differing ethnicity, habit, location, treatment and outcome.

PMID:
31058262
PMCID:
PMC6498857

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