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J Oncol Res Ther. 2017;3(4). pii: 132. Epub 2017 Sep 25.

Oral Squamous Cell Carcinomas are Associated with Poorer Outcome with Increasing Ages.

Lubpairee T1,2, Poh CF1,3,4, Laronde DM1,2,3, Rosin MP3,4,5, Zhang L1,2,3.

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Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia (BC), Vancouver, Canada.
BC Oral Cancer Prevention Program, BC Cancer Agency, Vancouver, Canada.
BC Oral Biopsy Service, Vancouver General Hospital, Vancouver, Canada.
BC Cancer Research Centre, Vancouver, Canada.
School of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.



1.1.Although oral cancers traditionally occur in people between the age of 50 and 70, there are increasing incidences of this disease in younger and very old people. Objectives: to compare the demographics, habits, clinicopathological features, treatment and outcome of oral cancer in three age groups of patients: Young (≤ 45), Traditional (46 to 75), and Old (> 75).


1.2.Primary oral cancers (393 patients) in a longitudinal study were used.


1.3.Significant differences were noted in ethnicity (fewer Caucasian patients in Young), tobacco habit (more non-smokers in Young), location of cancer (more at tongue for Young and more at low-risk sites for Old) and treatment (more surgery for Young). Compared to Young (univariate analysis), Traditional and Old showed a 3- and 4.5-fold increase in local recurrences respectively; 1.9- and 2.7-fold increase in regional metastasis; 3.1- and 5.4-fold increase in death due to disease; and a 3.4- and 6.6-fold decrease in overall survival. Compared to Young (multivariate analysis), Traditional and Old showed a 2.4- and 3.3-fold increase in local recurrence; 2.7- and 5.4-fold increase in disease-specific survival; and 2.8- and 6.5-fold decrease in overall survival.


1.4.Oral cancer in different age groups showed differing ethnicity, habit, location, treatment and outcome.


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