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Front Vet Sci. 2019 Apr 18;6:121. doi: 10.3389/fvets.2019.00121. eCollection 2019.

Pericardial Mesothelioma in a Dog: The Feasibility of Ultrasonography in Monitoring Tumor Progression.

Author information

1
Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, Fuchu, Japan.
2
Department of Pet Science and Technology, Shandong Vocational Animal Science and Veterinary College, Weifang, China.
3
Laboratory of Veterinary Pharmacology, Tokyo University of Agriculture and Technology, Fuchu, Japan.
4
Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Japan.
5
Laboratory of Veterinary Microbiology, Tokyo University of Agriculture and Technology, Fuchu, Japan.
6
Animal Medical Center, Tokyo University of Agriculture and Technology, Fuchu, Japan.

Abstract

A 6-year-old neutered male Yorkshire Terrier presented with recurrent pericardial effusion. Although clinical examinations including computed tomography were inconclusive, an exploratory thoracotomy revealed multiple small nodules and plaques on the inner surface of the pericardial sac (Day 1). A subtotal pericardiectomy was performed to prevent cardiac tamponade due to the increasing pericardial effusion, and the resected section of the pericardium was histopathologically diagnosed with mesothelioma. After surgery, chemotherapy with intrathoracic carboplatin was commenced. During the course of the treatment, a detailed follow-up ultrasonographic scan was performed to detect early lesions disseminated on the pleura, originating from the primary pericardial mesothelioma. On Day 101, the minute pleural nodules, which were disseminated lesions as predicted, were successfully imaged by ultrasonography. As the clinical stage advanced, the nodules were observed to gradually increase in size and number, implying tumor progression. These observations highlight the feasibility of ultrasonography in detecting minute disseminated lesions at an early stage, monitoring tumor progression, and thereby, predicting the prognosis of canine pericardial mesothelioma.

KEYWORDS:

dog; early detection; pericardial mesothelioma; pleural dissemination; ultrasonography

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