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J Biol Regul Homeost Agents. 2019 May 3;33(3). [Epub ahead of print]

Anti-calculus efficacy of Periogen® oral rinse in gingivitis patients.

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Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
POLYPHENO S.r.l., Accredited Spin Off, University of Bari Aldo Moro, Bari, Italy.
Sorriso e Benessere Ricerca e Clinica S.r.l., Bari, Italy.
Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari, Italy.
Dentist Education Institute, Athens, Greece.
Human Stem Cells Research Center, Ho Chi Minh City, Vietnam.
Contributed equally


Dental biofilm is a complex, organized microbial community that is the primary etiologic factor for plaque, the most frequently occurring oral contamination for gingivitis, dental caries and periodontal diseases. In dentistry, calculus is a form of hardened dental plaque, caused by precipitation of calcium (Ca) and phosphorous (P) ions deposited from saliva and gingival crevicular fluid. Although the dental biofilm cannot be eliminated, it can be controlled with comprehensive mechanical and chemotherapeutic oral hygiene practices. Chemotherapeutic agents have difficulty penetrating the polysaccharide matrix to reach and affect the microorganisms. The purpose of the present study was to evaluate the anti-calculus efficiency of a mouthwash containing an association of sodium tripolyphosphate, tetrapotassium pyrophosphate, sodium bicarbonate and citric acid in patients affected with gingivitis.


anti-calculus mouthwash; dental calculus; plaque index; salivary calcium; salivary phosphorus


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