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Oral Dis. 2019 May 6. doi: 10.1111/odi.13115. [Epub ahead of print]

Histone modifications in oral squamous cell carcinoma and oral potentially malignant disorders.

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State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine of West China Hospital of Stomatology, Sichuan University.
College of Stomatology, Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.


Oral squamous cell carcinomas (OSCC) is a common malignancy with dismal prognosis without effective therapeutic options in advanced cases. The evolution from oral potentially malignant disorders to OSCC has poorly described underlying epigenetic features. With the ability of silencing or activation of vital genes, histone modifications' and modifiers' potentiality for early diagnosis, prognosis predicting, and therapy in OSCC were evaluated by extensive epigenetic studies. This review investigates the roles of dysregulated histone modifications and the associated modifying enzymes in OSCC onset and progression. Also, we focus on the current advances of histone modifications as therapeutic targets and the potential value of epi-drugs. This article is protected by copyright. All rights reserved.


histone modifications; histone-modifying enzymes; inhibitors; malignant transformation; oral potentially malignant disorders; oral squamous cell carcinoma


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