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J Infect Dis. 2019 Aug 9;220(6):956-960. doi: 10.1093/infdis/jiz212.

Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial.

Author information

1
School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia.
2
Seattle Children's Hospital, Washington.
3
Department of Pediatrics, University of Washington, Seattle.
4
Department of Laboratory Medicine, University of Washington, Seattle.
5
Global Health, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia.
6
International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
7
Nepal Nutrition Intervention Project - Sarlahi, Kathmandu, Nepal.
8
Division of Allergy and Infectious Diseases, University of Washington, Seattle.

Abstract

In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection. Clinical Trials Registration. NCT01034254.

KEYWORDS:

RSV; hMPV; influenza; maternal immunization; pneumococcus; vaccine

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