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High Blood Press Cardiovasc Prev. 2019 Jun;26(3):175-182. doi: 10.1007/s40292-019-00318-4. Epub 2019 May 3.

Vascular Aging and Disease of the Large Vessels: Role of Inflammation.

Author information

1
School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
2
Cardiology 4, "A. De Gasperis" Department, Niguarda Ca Granda Hospital, Piazza Ospedale Maggiore 3, 20159, Milan, Italy.
3
School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. cristina.giannattasio@unimib.it.
4
Cardiology 4, "A. De Gasperis" Department, Niguarda Ca Granda Hospital, Piazza Ospedale Maggiore 3, 20159, Milan, Italy. cristina.giannattasio@unimib.it.

Abstract

Structural and functional arterial properties commonly impair with aging process. These effects on vasculature could act at many levels from microcirculation to large vessels. Above normal aging process classic cardio-vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, etc.) accelerate the physiological process leading to premature structural and functional alterations that has also been termed early vascular aging. Target organ damage evaluation could be clinically important since these alterations precede by many years' cardiovascular events and so their assessment can predict the onset of more serious and costly events giving the opportunity to prevent CV events by earlier therapeutic intervention. This review will focus on large artery functional properties and particularly on the role of inflammation on the aortic stiffening process.

KEYWORDS:

Arterial stiffness; Inflammation; Large vessels; Pulse wave velocity; Vascular aging

PMID:
31054064
DOI:
10.1007/s40292-019-00318-4
[Indexed for MEDLINE]

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