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Trends Neurosci. 2019 Jun;42(6):375-383. doi: 10.1016/j.tins.2019.03.007. Epub 2019 Apr 30.

Dopaminergic Vulnerability in Parkinson Disease: The Cost of Humans' Habitual Performance.

Author information

1
HM CINAC, Hospital Universitario HM Puerta del Sur, Mostoles, Madrid, Spain; Universidad CEU San Pablo, Madrid, Spain; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
2
Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal; Departments of Neuroscience and Neurology, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
3
Department of Psychology, University of Sheffield, Sheffield, S10 2TN, UK.
4
HM CINAC, Hospital Universitario HM Puerta del Sur, Mostoles, Madrid, Spain; Universidad CEU San Pablo, Madrid, Spain; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain. Electronic address: jobeso.hmcinac@hmhospitales.com.

Abstract

Humans can simultaneously combine automatic/habitual and voluntary/goal-directed aspects of behavioral control. Habitual routines permit us to perform well practiced task-components with minimal or no voluntary attention. Evidence from animal and human investigations indicates that dopaminergic neurons in lateral substantia nigra, which innervate the sensorimotor striatum, are engaged during the acquisition and performance of automatized skills and habits. Typically, in Parkinson disease (PD), there is a differential loss of dopamine, which occurs earliest and most severely in the caudal sensorimotor striatum, a subdivision of the striatum implicated in habitual control. We suggest that frequent reliance on habitual performance may be a critical functional stressor, which, when combined with other more general risk factors, could explain the selective neurodegeneration of the nigrostriatal motor projection in PD.

KEYWORDS:

Parkinson disease; dopamine; goal-directed behavior; habitual behavior; vulnerability

PMID:
31053241
DOI:
10.1016/j.tins.2019.03.007

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