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Pediatr Blood Cancer. 2019 Aug;66(8):e27779. doi: 10.1002/pbc.27779. Epub 2019 May 2.

Severe therapy-related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres.

Author information

1
Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
2
Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, Texas.
3
Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
4
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Abstract

Telomere biology disorders predispose affected individuals to specific malignancies and organ fibrosis in tissues sensitive to telomere length (TL) shortening, especially after exposure to chemotherapy and radiation. We report a case of a 17-year-old female with Hodgkin lymphoma who developed severe chemotherapy-related toxicities. She was subsequently found to have peripheral blood lymphocyte TL < 1st percentile and a pathogenic variant in TERT inherited from her father. This case demonstrates that early genetic evaluation of patients who experience greater than expected therapy-related toxicities may be warranted to help guide further decisions regarding therapy, imaging modalities, and lifelong cancer prevention surveillance.

KEYWORDS:

Hodgkin disease; MDS; late effects of cancer treatment; lymphoma; molecular genetics; telomerase

PMID:
31050187
DOI:
10.1002/pbc.27779
[Indexed for MEDLINE]

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