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Aging Clin Exp Res. 2019 Jun;31(6):845-854. doi: 10.1007/s40520-019-01208-4. Epub 2019 May 2.

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.

Author information

1
Frailty in Ageing Research Group (FRIA), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium.
2
Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands.
3
Department of Internal Medicine, Section of Gerontology and Geriatrics, VU University Medical Center, Amsterdam, The Netherlands.
4
Center of Geriatric Medicine, Heidelberg University, Heidelberg, Germany.
5
Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands.
6
Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
7
Department of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Human Nutrition, "Sapienza" University of Rome, Rome, Italy.
8
Department of Medicine and Surgery, Section of Geriatrics, University of Parma, Parma, Italy.
9
Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
10
Department of Public Health and Caring Nutrition Sciences/Clinical and Metabolism, Department of Geriatric Medicine, Uppsala University Hospital, Uppsala, Sweden.
11
Frailty in Ageing Research Group (FRIA), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium. ivan.bautmans@vub.be.

Abstract

BACKGROUND:

A chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited.

AIM:

To investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis.

METHODS:

Sarcopenic adults (low skeletal muscle mass) aged ≥ 65 years with mobility limitations (Short Physical Performance Battery 4-9) and a body mass index of 20-30 kg/m2 were randomly allocated to two daily servings of active (n = 137, including 20 g of whey protein, 3 g of leucine and 800 IU VitD) or isocaloric control product (n = 151) for a double-blind period of 13 weeks. At baseline and after 13 weeks, circulating interleukin (IL)-8, IL-1 receptor antagonist (RA), soluble tumor-necrosis-factor receptor (sTNFR)1, IL-6, high-sensitivity C-reactive protein, pre-albumin and 25-hydroxyvitamin(OH)D were measured. Data-analysis included repeated measures analysis of covariance (corrected for dietary VitD intake) and linear regression.

RESULTS:

IL-6 and IL-1Ra serum levels showed overall increases after 13 weeks (p = 0.006 and p < 0.001, respectively). For IL-6 a significant time × treatment interaction (p = 0.046) was observed, with no significant change over time in the active group (p = 0.155) compared to control (significant increase p = 0.012). IL-8 showed an overall significant decrease (p = 0.03). The change in pre-albumin was a significant predictor for changes in IL-6 after 13 weeks.

CONCLUSIONS:

We conclude that 13 weeks of nutritional supplementation with VitD and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations.

KEYWORDS:

Aged; Cytokines; Dietary supplements; Leucine; Vitamin D; Whey proteins

PMID:
31049877
DOI:
10.1007/s40520-019-01208-4

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