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Pediatr Radiol. 2019 Jul;49(8):1018-1024. doi: 10.1007/s00247-019-04411-7. Epub 2019 May 2.

Magnetic resonance imaging T1 relaxation times for the liver, pancreas and spleen in healthy children at 1.5 and 3 tesla.

Author information

1
Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5031, Cincinnati, OH, 45229, USA.
2
Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
3
Department of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
4
Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5031, Cincinnati, OH, 45229, USA. Andrew.Trout@cchmc.org.
5
Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Andrew.Trout@cchmc.org.

Abstract

BACKGROUND:

T1 relaxation time is a potential magnetic resonance imaging (MRI) biomarker for fibrosis and inflammation of the solid abdominal organs. However, normal T1 relaxation times of the solid abdominal organs have not been defined for children.

OBJECTIVE:

The purpose of this study was to measure T1 relaxation times of the liver, pancreas and spleen in healthy children.

MATERIALS AND METHODS:

This was an institutional review board-approved study of a convenience sample of prospectively recruited, healthy children ages 7 to 17 years undergoing research abdominal MRI (1.5 or 3 T) as part of a larger research study between February 2018 and October 2018. For the current study, T1 mapping was performed with a Modified Look-Locker sequence covering the upper abdomen. A single reviewer placed freehand regions of interest on the T1 parametric maps in the liver, pancreas and spleen, inclusive of as much parenchyma as possible. Student's t-tests and linear regression were used to compare T1 values by age and gender.

RESULTS:

Thirty-two participants were included (16 female:16 male; mean age: 12.2±3.1 years; n=16 at 1.5 T). Median T1 relaxation times (ms) per organ were liver: 581±64 (1.5 T), 783±88 (3 T); pancreas: 576±55 (1.5 T), 730±30 (3 T), and spleen: 1,172±71 (1.5 T), 1,356±87 (3 T). T1 values were not statistically significantly different between males and females. At both 1.5 and 3 T field strengths, linear regression showed no significant association between age and T1 values for the liver, pancreas and spleen.

CONCLUSION:

We report normal T1 relaxation times for the liver, pancreas and spleen at 1.5 and 3 T in a cohort of healthy children.

KEYWORDS:

Children; Liver; Look-locker; Magnetic resonance imaging; Pancreas; Spleen; T1 mapping

PMID:
31049609
DOI:
10.1007/s00247-019-04411-7

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